Article
Single amino acid substitution in constant region 1 or 4 of gp120 causes the phenotype of a human immunodeficiency virus type 1 variant with mutations in hypervariable regions 1 and 2 to revert.
Journal of virology - 1 Jan 1996
Wang W K, Essex M, Lee T H
Abstract excerpt
The second major cysteine loop of human immunodeficiency virus type 1 envelope glycoprotein gp120 contains 5 to 11 consensus N-linked glycosylation sites, which is disproportionately higher than the number of such sites found in other regions of gp120. Amino acid substitutions introduced at three...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Cloning, Molecular
- DNA Primers
- Genetic Variation
- Glycosylation
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Phenotype