Effects of mutations in constant regions 3 and 4 of envelope of simian immunodeficiency virus.

Abstract excerpt

Twenty-six mutant forms of simian immunodeficiency virus strain mac239 were constructed with changes in constant region 4 (C4) of env. Twenty-four of these had a single amino acid change, one had changes in two amino acids, and one had a deletion of eight amino acids. The effects of these mutations on viral replication, gp160 processing, and binding of env protein to soluble CD4 receptor were analyzed. The C4...

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