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Article

Role of interferon-gamma in contact hypersensitivity assessed in interferon-gamma receptor-deficient mice.

Toxicology - 18 Sept 1995

Saulnier M, Huang S, Aguet M, Ryffel B

Abstract excerpt

The role of interferon-gamma (IFN gamma) in contact hypersensitivity induced by the haptens, oxazolone and 2,4,6-trinitrochlorobenzene (TNCB), was investigated in mice with a targeted disruption of the IFN gamma receptor (IFN gamma-R-/-). The 24-h ear-swelling response to oxazolone or TNCB in sensitized animals was not significantly reduced by the disruption of IFN gamma signalling. Dermal mononuclear infiltrates...

Topics

Adjuvants, Immunologic
Animals
Dermatitis, Contact
Female
Genotype
Haptens
Histocompatibility Antigens Class II
Interferon-gamma
Major Histocompatibility Complex
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Oxazolone

Picryl Chloride

Receptors, Interferon

Up-Regulation

Source

Identifiers

PMID: 7482569
DOI: 10.1016/0300-483x(95)03101-k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7482569-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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