Article
Role of interferon-gamma in contact hypersensitivity assessed in interferon-gamma receptor-deficient mice.
Toxicology - 18 Sept 1995
Saulnier M, Huang S, Aguet M, Ryffel B
Abstract excerpt
The role of interferon-gamma (IFN gamma) in contact hypersensitivity induced by the haptens, oxazolone and 2,4,6-trinitrochlorobenzene (TNCB), was investigated in mice with a targeted disruption of the IFN gamma receptor (IFN gamma-R-/-). The 24-h ear-swelling response to oxazolone or TNCB in sensitized animals was not significantly reduced by the disruption of IFN gamma signalling. Dermal mononuclear infiltrates...
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