Cytokine knockout mice: possible application in toxicological research.

Abstract excerpt

Knockout mice obtained by homologous recombination technology may be valuable tools for in vivo investigations in toxico-pathogenesis. A short review of the phenotype of mice with distinct cytokine deletions, which occur either naturally or are obtained by homologous recombination, is given. The possible application in pharmacological and toxicological research is discussed with examples of endotoxic shock,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autoimmune Diseases
• Share to Cytokines
• Share to Hematopoiesis