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Article

Role of IFN-gamma in an experimental murine model of West Nile virus-induced seizures.

Journal of neurochemistry - 1 Nov 2007

Getts Daniel R, Matsumoto Izuru, Müller Marcus, Getts Meghann Teague, Radford Jane, Shrestha Bimmi, Campbell Iain L, King Nicholas J C

Abstract excerpt

Seizures are a major complication of viral encephalitis. However, the mechanisms of seizure-associated neuronal dysfunction remain poorly understood. We report that intranasal inoculation with West Nile virus (WNV) (Sarafend) causes limbic seizures in C57BL/6 mice, but not in interferon (IFN)-gamma-deficient (IFN-gamma-/-) mice. Both strains showed similar levels of virus in the brain, as well as similar...

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PMID: 17854352
DOI: 10.1111/j.1471-4159.2007.04798.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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