Article
Transgenic mice expressing IFN-gamma in the epidermis have eczema, hair hypopigmentation, and hair loss.
The Journal of investigative dermatology - 1 Apr 1997
Carroll J M, Crompton T, Seery J P, Watt F M
Abstract excerpt
To study the role of IFN-gamma in the pathogenesis of inflammatory skin diseases, we used the involucrin promoter to overexpress IFN-gamma in the suprabasal layers of transgenic mouse epidermis. IFN-gamma mRNA and protein were readily detectable in the skin but not in the blood. Mice exhibited st...
Topics
- Animals
- Antibody Formation
- Cell Differentiation
- Cell Division
- Dermatitis, Contact
- Eczema
- Gene Expression
- Hair Color
- Histocompatibility Antigens Class II
- Hypotrichosis
- Intercellular Adhesion Molecule-1
- Interferon-gamma
- Keratinocytes
- Mice
- Mice, Transgenic
- Phenotype
- Receptors, Interferon
- Skin