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Article

Wild type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13).

The Journal of biological chemistry - 14 Apr 2000

Sun Y, Cheung J M, Martel-Pelletier J, Pelletier J P, Wenger L, Altman R D, Howell D S, Cheung H S

Abstract excerpt

Matrix metalloproteinases (MMPs) are a family of secreted or transmembrane proteins that can degrade all the proteins of the extracellular matrix and have been implicated in many abnormal physiological conditions including arthritis and cancer metastasis. Recently we have shown for the first time that the human MMP-1 gene is a p53 target gene subject to repression by wild type p53 (Sun, Y., Sun, Y. I., Wenger,...

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Topics

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Share to Arthritis, Rheumatoid
Share to Collagenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Matrix Metalloproteinase 13

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Share to Promoter Regions, Genetic

Share to Response Elements

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 10753945
DOI: 10.1074/jbc.275.15.11327

Genes

MMP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Wild type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13).PMID 10753945Read ↗

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