Article
[Variability of the virulent properties of influenza A viruses in recombination].
Voprosy virusologii - 1 Jan 2000
Zazimko L A, Vakin V S, Kozinets I A, Zakharova N G
Abstract excerpt
The pattern of redistribution of human virulence in epidemic strains of influenza viruses in recombination with human avirulent strains was studied. In the course of recombination of epidemic and attenuated influenza virus strains variants with different human virulence were obtained. Some recombinants manifested enforced reactogenic properties as compared with the epidemic strain (X/28, M/35, and 0/26--H1N1, and...
Topics
- Adult
- Animals
- Chick Embryo
- Genetic Variation
- Humans
- Immunization
- Influenza A virus
- Recombination, Genetic
- Rimantadine
- Virulence
