Differing activation pathways for 2-acetylaminofluorene to a mutagen in vitro.

doi:10.1016/0165-1218(82)90144-6

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Article

Differing activation pathways for 2-acetylaminofluorene to a mutagen in vitro.

Mutation research - 1 Jan 2000

McGregor D B, McConville M, Menzies C, Prentice R D

Abstract excerpt

The mutagenicity of 2-acetylaminofluorene (AAF) in S. typhimurium TA 1538 was investigated using Ames' test and activation systems based upon rat- or cotton rat-liver post-mitochondrial supernatant (S9) fractions. Part of this study involved sub-fractionation of S9 into microsomes (M) and 100,000...

Topics

2-Acetylaminofluorene
Animals
Biotransformation
Freezing
Kinetics
Male
Microsomes, Liver
Mutagenicity Tests
Mutagens
Mutation
Rats
Salmonella typhimurium

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