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Article

Chemical models for cytochrome P450 as a biomimetic metabolic activation system in mutation assays.

Mutation research - 26 Aug 2002

Inami Keiko, Mochizuki Masataka

Abstract excerpt

DNA damage is a critical factor in carcinogenesis. The Ames assay is a short-term test that screens for DNA-damaging agents. To be detected in the assay, most carcinogens require oxidation by cytochrome P450, a component of the liver homogenate preparation (S9 mix) that is traditionally used to metabolize promutagens to an active form in vitro. A combination of iron(III) porphyrin plus an oxidant activates many...

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PMID: 12160898
DOI: 10.1016/s1383-5718(02)00132-8

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