Metabolic activation capabilities of S9 and hepatocytes from uninduced rats to convert carcinogenic N-nitrosamines to mutagens.

doi:10.1016/0165-7992(84)90060-5

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Article

Metabolic activation capabilities of S9 and hepatocytes from uninduced rats to convert carcinogenic N-nitrosamines to mutagens.

Mutation research - 1 Jan 2000

Rumruen K, Pool B L

Abstract excerpt

6 carcinogenic nitrosamines were studied in Salmonella typhimurium TA1535 after activation by S9 and by hepatocytes. All nitrosamines were activated by S9 from induced rats, regardless of their organotropy. The hepatocarcinogenic nitrosamines (N-nitrosodimethylamine, NDMA; N-nitrosodiethylamine,...

Topics

Animals
Biotransformation
Cytochromes
Liver
Male
Microsomes, Liver
Mutagenicity Tests
Mutagens
Mutation
Nitrosamines
Rats
Rats, Inbred Strains
Salmonella typhimurium

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