Article
Androgen receptor-mediated genetic differences in 2-acetylaminofluorene and dimethylnitrosamine mutagenesis in vitro.
Anticancer research - 1 Jan 2000
Fysh J M, Andrews L S, Nebert D W
Abstract excerpt
When 2-acetylaminofluorene and dimethylnitrosamine mutagenesis rates in the Salmonella/liver in vitro system were studied with C3H/HeJ mouse kidney or liver postmitochondrial supernatant (S-9) fractions, sex differences (male much greater than female) of 10- to 30-fold were found in kidney but not liver. We examined male mice castrated during the neonatal period, the Tfm/Y male, and dihydrotestosterone-treated...
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