Article
Effect of rat liver cytosolic enzymes and cofactors on mutagenicity of 1-amino-8-nitropyrene.
Carcinogenesis - 1 Feb 1991
Martire G, Villani G R, Della Morte R, Belisario M A, Pecce R, Staiano N
Abstract excerpt
1-Amino-8-nitropyrene (1,8-ANP), a product of 1,8-dinitropyrene metabolism by either bacterial or mammalian enzymes, is weakly mutagenic to the 'classical nitroreductase'-deficient Salmonella tester strain TA98NR. The addition to the test system of rat liver cytosol without cofactors did not produce any effect on the 1,8-ANP mutagenic response toward TA98NR strain. Conversely, when both rat hepatic cytosol and...
Topics
- Acetyl Coenzyme A
- Acetyltransferases
- Adenosine Phosphosulfate
- Animals
- Cattle
- Cytosol
- DNA
- DNA, Bacterial
- Liver
- Male
- Mutagenicity Tests
- Mutation