Article
Bladder and liver tumorigenesis induced by 2-acetylaminofluorene in different F1 mouse hybrids: variation within genotypes and effects of using more than one genotype on risk assessment.
Journal of toxicology and environmental health - 1 Jul 1991
Wolff G L, Gaylor D W, Blackwell B N, Moore G E
Abstract excerpt
Several F1 mouse hybrids were used in a chronic bioassay to determine whether such an experimental design would provide greater statistical power than using only the B6C3F1 hybrid. For this purpose, the dose response of formation of hepatocellular and bladder tumors after 30 mo of feeding 2-acetylaminofluorene (2-AAF) in the diet was assessed in 4 F1 mouse hybrids, including the B6C3F1 hybrid. No strain...
Topics
- 2-Acetylaminofluorene
- Animals
- Carcinoma
- Female
- Genotype
- Liver Neoplasms, Experimental
- Male
- Mice
- Papilloma
- Risk Factors
- Sex Factors