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Article

Hemoglobin adduct and hepatic- and urinary bladder-DNA adduct levels in rapid and slow acetylator Syrian inbred hamsters administered 2-aminofluorene.

The Journal of pharmacology and experimental therapeutics - 1 Feb 1992

Flammang T J, Yerokun T, Bryant M S, Couch L H, Kirlin W G, Lee K J, Ogolla F, Ferguson R J, Talaska G, Hein D W

Abstract excerpt

The levels of covalently bound arylamine-hemoglobin and DNA adduct formation were used as dosimeters to measure the effect of acetylator genotype and sex on the metabolic conversion of the carcinogen, 2-aminofluorene, to reactive intermediates. A single high dose of 2-aminofluorene (60 mg/kg b.wt. i.p.) was administered to male and female homozygous rapid (Patr/Patr) acetylator hamsters (MHA/SsLaK) and homozygous...

Topics

Acetylation
Animals
Cricetinae
DNA
DNA Damage
Female
Fluorenes
Gas Chromatography-Mass Spectrometry
Genotype
Hemoglobins
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Male

Mesocricetus

Mutagens

Urinary Bladder

Source

Identifiers

PMID: 1738128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1738128-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Hemoglobin adduct and hepatic- and urinary bladder-DNA adduct levels in rapid and slow acetylator Syrian inbred hamsters administered 2-aminofluorene.PMID 1738128Read ↗

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