Article
Mutagenic activation of 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole(Trp-P-1) and 3-amino-1-methyl-5H-pyrido(4,3-b)indole (Trp-P-2) by primary cultures of adult rat hepatocytes: effect of Aroclor induction in vitro.
Mutation research - 1 Jan 2000
Decloître F, Hamon G, Martin M, Thybaud-Lambay V
Abstract excerpt
The mutagenic activation of tryptophan pyrolysis products, Trp-P-1 and Trp-P-2, was studied in a Salmonella TA98/hepatocyte mutagenesis assay. Adult rat hepatocytes in primary culture were either untreated or induced by the addition of Aroclor 1254 (2 micrograms/ml) 18-20 h before the mutagenesis...
Topics
- Animals
- Aroclors
- Biotransformation
- Carbolines
- Cells, Cultured
- Chlorodiphenyl (54% Chlorine)
- Indoles
- Kinetics
- Liver
- Male
- Microsomes, Liver
- Mutagenicity Tests
- Mutagens
- Mutation
- Polychlorinated Biphenyls
- Rats
- Rats, Inbred Strains
- Salmonella typhimurium