Article
Certain tryptophan photoproducts are inhibitors of cytochrome P450-dependent mutagenicity.
Environmental and molecular mutagenesis - 1 Jan 1992
Rannug U, Agurell E, Rannug A, Cederberg H
Abstract excerpt
Two photoproducts, derived from UV-irradiation of the amino acid L-tryptophan and with high Ah (TCDD) receptor binding affinity, were tested for genotoxic and antimutagenic effects. The two indolo[3,2-b]carbazole derivatives, with the molecular weights of 284 and 312, respectively, were tested in...
Topics
- Alkaloids
- Animals
- Antimutagenic Agents
- CHO Cells
- Carbazoles
- Cricetinae
- Cricetulus
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System
- Gene Conversion
- Hypoxanthine Phosphoribosyltransferase
- Indole Alkaloids
- Indoles
- Male
- Mutagenesis
- Mutagenicity Tests
- Mutagens