Article
The adaptable somatic repertoire.
Annales d'immunologie - 1 Jan 2000
Gearhart P J
Abstract excerpt
Somatic mutation introduces singles nucleotide substitutions in and around the rearranged kappa variable gene, Vk167, but not the constant gene. The high frequency of mutations is most easily explained by a mechanism of error-prone repair which occurs during several cycles of cell division. Mutat...
Topics
- Amino Acid Sequence
- Animals
- Antibody Diversity
- Base Sequence
- DNA Repair
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin Light Chains
- Immunoglobulin kappa-Chains
- Mice
- Mutation
- Phosphorylcholine