Article
The adaptable somatic repertoire.
Annales d'immunologie - 1 Jan 2000
Gearhart P J
Abstract excerpt
Somatic mutation introduces singles nucleotide substitutions in and around the rearranged kappa variable gene, Vk167, but not the constant gene. The high frequency of mutations is most easily explained by a mechanism of error-prone repair which occurs during several cycles of cell division. Mutations may accumulate with time after joining of the V- and J-gene segments because IgG and IgA antibodies contain more...
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