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Article

Induction of forward mutations at the thymidine kinase locus of mouse lymphoma cells: evidence for electrophilic and non-electrophilic mechanisms.

Mutation research - 2 Feb 1998

Henry B, Grant S G, Klopman G, Rosenkranz H S

Abstract excerpt

A database of 209 chemicals tested for induction of forward mutations at the heterozygous thymidine kinase (TK +/-) locus in L5178Y mouse lymphoma cells was analyzed for structure-activity relationships using the MultiCASE expert system. Consistent with evidence of several contributing biological...

Topics

Animals
Databases, Factual
Lymphoma
Mice
Mutagenicity Tests
Mutagens
Mutation
Salmonella typhimurium
Structure-Activity Relationship
Thymidine Kinase
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9541657
DOI: 10.1016/s0027-5107(97)00231-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9541657-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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