Article
Activation of mutagens in cooked ground beef by human-liver microsomes.
Mutation research - 1 Jan 2000
Felton J S, Healy S K
Abstract excerpt
The total organic base fraction purified from fried ground beef is metabolized by human-liver microsomes to form mutagens detectable by the Ames/Salmonella bacterial assay. The mutagens produced have an absolute requirement for metabolic activation; without it, no increase in the number of revert...
Topics
- Animals
- Aroclors
- Biotransformation
- Cattle
- Chlorodiphenyl (54% Chlorine)
- Cooking
- Hot Temperature
- Humans
- Male
- Meat
- Mice
- Microsomes, Liver
- Mutagenicity Tests
- Mutagens
- Mutation
- Rats
- Rats, Inbred Strains
- Salmonella typhimurium