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Article

Genotoxic effects of aristolochic acid I on functional human-induced hepatocyte-like cells

26 May 2025

Abstract excerpt

Aristolochic acid I (AAI) is a carcinogen associated with various human cancers. However, its causal relationship with hepatocellular carcinoma remains controversial, and inconsistent results from rodent studies have suggested species-specific differences. Here we evaluated AAI genotoxicity using functional human-induced hepatocyte-like cells (hiHep cells), a model that closely mimics primary human hepatocytes in...

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PMID: 40417995
DOI: 10.1093/mutage/geaf012

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