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Article

Biological significance of trace levels of mutagenic heterocyclic aromatic amines in human diet: a critical review.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Oct 1994

Stavric B

Abstract excerpt

Cooking of protein-rich foods may induce the formation of a series of heterocyclic aromatic amines (HAAs) that have been found to be mutagens and carcinogens. Despite very potent mutagenic activity found in the Salmonella/microsomal assay, this test cannot predict carcinogenic potency of HAAs in rodents and monkeys. Doses used in the feeding studies with animals exceeded by several orders of magnitude the levels...

Topics

Amines
Animals
Biological Availability
Carcinogens
Diet
Female
Food Analysis
Heterocyclic Compounds
Humans
Liver
Male
Mutagens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasms

Risk Factors

Sex Characteristics

Species Specificity

Source

Identifiers

PMID: 7959450
DOI: 10.1016/0278-6915(94)90093-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7959450-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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