Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential genotoxicity of Polygoni Multiflori in rat and human: insights from Ames test and S9 metabolic activation system.

Scientific reports - 13 Sept 2024

Bak Su-Min, Back Seng-Min, Kim Da Yeon, Jung Soyoung, Jeung Na-Young, Kim Nan-Young, Han Kang-Hyun, Kim Yong-Bum, Lee Byoung-Seok, Park Jun Hong, Cho Hee Jun, Lee Hee Gu, Ozden Ozkan, Kim Sang Kyum, Park Seong-Hoon

Abstract excerpt

The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with substances with/without cytochrome P450s (CYPs)-induced rat S9 fractions for identifying mutagens and pro-mutagens. However, many substances show completely different toxicity patterns...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 Enzyme System
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Mutagenicity Tests

Share to Mutagens

Share to Salmonella typhimurium

Source

Open in PubMed Open full text

Identifiers

PMID: 39271730
DOI: 10.1038/s41598-024-72283-5
PMCID: PMC11399298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential genotoxicity of Polygoni Multiflori in rat and human: insights from Ames test and S9 metabolic activation system.PMID 39271730Read ↗

Differential Genotoxicity of Polygoni Multiflori in Rat and Human: Insights from Ames Test and S9 Metabolic Activation SystemSemantic proximity Read ↗

Systematic analysis of gut bacterial carcinogen metabolism and its functional consequencesSemantic proximity Read ↗

Alternatives to the carcinogenicity bioassay:<i>in silico</i>methods, and the<i>in vitro</i>and<i>in vivo</i>mutagenicity assaysSemantic proximity Read ↗

Mutagenicity Evaluation of Nanoparticles by the Ames Assay.Semantic proximity Read ↗

Mutagenicity of 30 Chinese herbs and pharmaceuticals.Semantic proximity Read ↗

Mutagenicity in a Molecule: Identification of Core Structural Features of Mutagenicity Using a Scaffold AnalysisSemantic proximity Read ↗

Identification of the Structural Requirements for Mutagenicity by Incorporating Molecular Flexibility and Metabolic Activation of Chemicals I: TA100 ModelSemantic proximity Read ↗

Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test.Semantic proximity Read ↗

Whether aristolochic acid directly drives hepatocarcinogenesis: comprehensive investigations from mutational signatures to animal models.Semantic proximity Read ↗

Assessing the impact of different solvents in the bacterial reverse mutation test.Semantic proximity Read ↗

Genotoxicity guidelines recommended by International Conference of Harmonization (ICH).Semantic proximity Read ↗

A review of human carcinogens—Part A: pharmaceuticalsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.