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Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid

23 Oct 2013

Abstract excerpt

1. Aristolochic acid I (AAI) is the predominant component in plant extract of Aristolochia genus that is involved in development of aristolochic acid nephropathy, Balkan endemic nephropathy and urothelial cancer. The diseases do not develop in all individuals exposed to AAI and patients exhibit different clinical outcomes. Differences in the activities of enzymes catalyzing the metabolism of AAI might be one of...

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PMID: 24152141
DOI: 10.3109/00498254.2013.848310

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