Article
In vivo genotoxicity of a novel heterocyclic amine, aminobenzoazepinoquinolinone-derivative (ABAQ), produced by the Maillard reaction between glucose and l-tryptophan.
Mutation research. Genetic toxicology and environmental mutagenesis - 15 Jan 2014
Totsuka Yukari, Watanabe Tetsushi, Coulibaly Souleymane, Kobayashi Sae, Nishizaki Marina, Okazaki Miho, Hasei Tomohiro, Wakabayashi Keiji, Nakagama Hitoshi
Abstract excerpt
We recently demonstrated that a novel heterocyclic amine, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), is produced from glucose and l-tryptophan by the Maillard reaction at physiological temperature and pH, and that ABAQ was strongly mutagenic for Salmonella strains in the presence of S9 mix. Here, we present the results of three in vivo genotoxicity assays of ABAQ. The comet assay...
Topics
- Animals
- Benzazepines
- Bone Marrow
- Comet Assay
- DNA Damage
- DNA-Binding Proteins
- Escherichia coli Proteins
- Glucose
- Hydroxyquinolines
- Imidazoles