Article
Metabolic formation, synthesis and genotoxicity of the N-hydroxy derivative of the food mutagen 2-amino-1-methyl-6-phenylimidazo (4,5-b) pyridine (PhIP).
Mutagenesis - 1 Jan 1991
Frandsen H, Rasmussen E S, Nielsen P A, Farmer P, Dragsted L, Larsen J C
Abstract excerpt
Hepatic microsomes from rats pretreated with PCB were found to metabolize the food mutagen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) to two major metabolites, one of which was identified as the N-hydroxy derivative, 2-hydroxy-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (N-OH-PhIP)....
Topics
- Animals
- Biotransformation
- Cell Line
- Chromatography, High Pressure Liquid
- Female
- Food
- Imidazoles
- Magnetic Resonance Spectroscopy
- Male
- Mass Spectrometry
- Microsomes, Liver
- Mutagens
- Mutation
- Nitroimidazoles
- Polychlorinated Biphenyls
- Pyridines
- Rats
- Rats, Inbred Strains