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Article

Mechanism of ribosome frameshifting during translation of the genetic code.

Nature - 1 Jan 2000

Weiss R, Gallant J

Abstract excerpt

Some frameshift mutations are strongly suppressed by limitation for particular aminoacyl-tRNA species. Here, we show that ribosome frameshifting at a specific tryptophan codon during Trp-tRNA limitation accounts for suppression of a group of downstream frameshift alleles in the rIIB gene of bacteriophage T4. Genetic and physiological observations strongly suggest that ribosome frameshifting at this position...

Topics

Codon
Escherichia coli
Genetic Code
Phenotype
Protein Biosynthesis
RNA, Messenger
RNA, Transfer, Amino Acyl
Ribosomes
Suppression, Genetic
Tryptophan

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 6339944
DOI: 10.1038/302389a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6339944-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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