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Article

A molecular characterization of spontaneous frameshift mutagenesis within the trpA gene of Escherichia coli.

DNA repair - 4 Feb 2007

Hardin Aaron, Villalta Christopher F, Doan Michael, Jabri Mouna, Chockalingham Valliammal, White Steven J, Fowler Robert G

Abstract excerpt

Spontaneous frameshift mutations are an important source of genetic variation in all species and cause a large number of genetic disorders in humans. To enhance our understanding of the molecular mechanisms of frameshift mutagenesis, 583 spontaneous Trp+ revertants of two trpA frameshift alleles in Escherichia coli were isolated and DNA sequenced. In order to measure the contribution of methyl-directed mismatch...

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Identifiers

PMID: 17084112
DOI: 10.1016/j.dnarep.2006.09.007
PMCID: PMC1804121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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