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Article

Experimental metastasis correlates with cyclic AMP accumulation in B16 melanoma clones.

Nature - 1 Jan 2000

Sheppard J R, Koestler T P, Corwin S P, Buscarino C, Doll J, Lester B, Greig R G, Poste G

Abstract excerpt

Metastasis is a complex process whereby tumour cells from a primary neoplastic growth disseminate throughout the body and establish secondary tumour foci in distant organs. Biochemical traits associated with, or essential for, the expression of the metastatic phenotype have not yet been identified. In the course of examining stimulation of the B16 murine melanoma adenylate cyclase by melanocyte-stimulating...

Topics

Animals
Cell Line
Clone Cells
Colforsin
Cyclic AMP
Diterpenes
Kinetics
Melanocyte-Stimulating Hormones
Melanoma
Mice
Phenotype

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Identifiers

PMID: 6323999
DOI: 10.1038/308544a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6323999-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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