Article
B16 mouse melanoma cells selected for resistance to cyclic AMP-mediated growth inhibition are cross-resistant to retinoic acid-induced growth inhibition.
Journal of cellular physiology - 1 Apr 1991
Niles R M, Loewy B
Abstract excerpt
B16 mouse melanoma cells are grown inhibited by cyclic AMP or by retinoic acid (RA). However, the combination of these two agents results in less growth inhibition than either agent alone. In order to investigate this interaction, cells were selected for resistance to 8-bromo-cyclic AMP-induced growth inhibition. Two clones (3 and 7) which demonstrated significant resistance were isolated. When these two clones...
Topics
- Animals
- Biological Transport
- Cell Division
- Clone Cells
- Cyclic AMP
- Dose-Response Relationship, Drug
- Growth Inhibitors
- Melanoma, Experimental
- Mice
- Mutation
- Protein Kinase C