Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli.

doi:10.1038/311232a0

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Article

Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli.

Nature - 1 Jan 2000

Ebright R H, Cossart P, Gicquel-Sanzey B, Beckwith J

Abstract excerpt

Three mutations that alter the DNA sequence specificity of the catabolite gene activator protein (CAP) from AA-TGTGA--T---TCA-ATW to AA-TGTAA--T---TCA-ATW have been isolated. All three mutations affect the same amino acid of CAP, glutamic acid 181. We propose that it is this amino acid of CAP tha...

Topics

Amino Acid Sequence
Base Sequence
Chromosome Mapping
Cyclic AMP
DNA-Binding Proteins
Escherichia coli
Gene Expression Regulation
Lac Operon
Mutation
Receptors, Cyclic AMP
Structure-Activity Relationship

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