Article
-11 Mutation in the ampC promoter increasing resistance to beta-lactams in a clinical Escherichia coli strain.
Antimicrobial agents and chemotherapy - 1 Oct 2002
Corvec S, Caroff N, Espaze E, Marraillac J, Reynaud A
Abstract excerpt
A mutation was discovered in the Pribnow box of the ampC promoter in a clinical Escherichia coli strain. This -11 C-to-T transition created a perfect homology with the -10 consensus sequence. The new promoter was cloned upstream of the cat gene of pKK232-8 and induced a sixfold increase in promoter strength.
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