Article
High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man.
Pharmaceutisch weekblad. Scientific edition - 14 Dec 1990
Vree T B, Beneken Kolmer E W, Hekster Y A
Abstract excerpt
A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, less than 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator.
Topics
- Acetylation
- Chromatography, High Pressure Liquid
- Glucuronates
- Glucuronidase
- Half-Life
- Humans
- Male
- Phenotype
- Protein Binding
- Sulfaphenazole