Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer's disease.

doi:10.1038/s41467-026-72310-1

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Article

Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer's disease.

Nature communications - 23 Sept 2026

Chandrashekar Pramod Bharadwaj, Alatkar Sayali Anil, Cohen Kalafut Noah, Jin Ting, Gupta Chirag, Burczak Ryan Conway, Huang Xiang, Liu Shuang, Li Athan Z, Girdhar Kiran, Voloudakis Georgios, Hoffman Gabriel E, Bendl Jaroslav, Fullard John F, Lee Donghoon, Roussos Panos, Wang Daifeng

Abstract excerpt

Alzheimer's disease (AD) is highly heterogeneous and driven by diverse molecular and cellular mechanisms. Functional genomics investigates these mechanisms from genetic variants to gene expression and regulation. We performed personalized functional genomics analysis on population-scale single-nucleus RNA-seq data, with cross-cohort validation across multiple cohorts comprising over 1900 individual brains,...

Read the complete abstract on PubMed

Topics

Alzheimer Disease
Humans
Single-Cell Analysis
Gene Regulatory Networks
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Single-Cell Gene Expression Analysis

Transcriptome

Graph Neural Networks

Gene Expression Profiling

Genetic Variation

Genomics

Brain

Phenotype

Source

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Identifiers

PMID: 42778537
DOI: 10.1038/s41467-026-72310-1
PMCID: PMC13601579

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