Article
MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.
PloS one - 1 Jan 2012
Ryland Georgina L, Bearfoot Jennifer L, Doyle Maria A, Boyle Samantha E, Choong David Y H, Rowley Simone M, Tothill Richard W, Gorringe Kylie L, Campbell Ian G
Abstract excerpt
MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer. MiRNA function is most often achieved through binding to the 3'-untranslated region of the target protein coding gene. Mutation screening using massively-parallel sequencing of 712 miRNA genes in 86 ovarian cancer cases identified only 5 mutated miRNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.