Article
Molecular underpinnings of metastatic small renal masses.
JCI insight - 22 Sept 2026
Kapur Payal, Beshnova Daria, Zhong Hua, Sharma Ruby, Ghatalia Pooja, Yoo Angela, Le Daniel D, Mukhopadhyay Ratna, Christie Alana, Miyata Jeffrey, Wei Shuanzeng, McKay Rana R, Rakheja Dinesh, Rajaram Satwik, Uzzo Robert G, Hakimi A Ari, Modrusan Zora, Brugarolas James
Abstract excerpt
Metastases in renal cell carcinoma (RCC) typically arise from large primary tumors. However, a subset of patients with small renal masses (SRMs; ≤4 cm) can develop metastatic disease. Identifying these tumors is clinically important, as many SRMs are managed with active surveillance, and their study may provide insight into the early acquisition of metastatic competence. It remains unclear whether these tumors...
Read the complete abstract on PubMedTopics
- Humans
- Kidney Neoplasms
- Carcinoma, Renal Cell
- TOR Serine-Threonine Kinases
- Exome Sequencing