Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.

doi:10.1016/j.cell.2018.03.057

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Article

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.

Cell - 19 Apr 2018

Turajlic Samra, Xu Hang, Litchfield Kevin, Rowan Andrew, Chambers Tim, Lopez Jose I, Nicol David, O'Brien Tim, Larkin James, Horswell Stuart, Stares Mark, Au Lewis, Jamal-Hanjani Mariam, Challacombe Ben, Chandra Ashish, Hazell Steve, Eichler-Jonsson Claudia, Soultati Aspasia, Chowdhury Simon, Rudman Sarah, Lynch Joanna, Fernando Archana, Stamp Gordon, Nye Emma, Jabbar Faiz, Spain Lavinia, Lall Sharanpreet, Guarch Rosa, Falzon Mary, Proctor Ian, Pickering Lisa, Gore Martin, Watkins Thomas B K, Ward Sophia, Stewart Aengus, DiNatale Renzo, Becerra Maria F, Reznik Ed, Hsieh James J, Richmond Todd A, Mayhew George F, Hill Samantha M, McNally Catherine D, Jones Carol, Rosenbaum Heidi, Stanislaw Stacey, Burgess Daniel L, Alexander Nelson R, Swanton Charles

Abstract excerpt

Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic competence was afforded by chromosome complexity, and we identify 9p loss as a highly selected event driving metastasis...

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Identifiers

PMID: 29656895
DOI: 10.1016/j.cell.2018.03.057
PMCID: PMC5938365

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