Article
Pancreatic tropism of metastatic renal cell carcinoma.
JCI insight - 9 Apr 2020
Singla Nirmish, Xie Zhiqun, Zhang Ze, Gao Ming, Yousuf Qurratulain, Onabolu Oreoluwa, McKenzie Tiffani, Tcheuyap Vanina Toffessi, Ma Yuanqing, Choi Jacob, McKay Renee, Christie Alana, Torras Oscar Reig, Bowman Isaac A, Margulis Vitaly, Pedrosa Ivan, Przybycin Christopher, Wang Tao, Kapur Payal, Rini Brian, Brugarolas James
Abstract excerpt
Renal cell carcinoma (RCC) is characterized by a particularly broad metastatic swath, and, enigmatically, when the pancreas is a destination, the disease is associated with improved survival. Intrigued by this observation, we sought to characterize the clinical behavior, therapeutic implications, and underlying biology. While pancreatic metastases (PM) are infrequent, we identified 31 patients across 2...
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