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Article

Associations of polymorphisms in the myeloid immunoregulatory receptor gene MRC1 with expression and prognosis in acute myeloid leukemia.

Frontiers in immunology - 1 Jan 2026

Li Meng, Yin Fangjing, Shi Zhiyu, Sun Tao, Ji Chunyan, Li Mingying

Abstract excerpt

Background: Acute myeloid leukemia (AML) shows substantial biological and clinical heterogeneity that extends beyond leukemia-intrinsic genetic alterations. MRC1, which encodes the myeloid receptor CD206, has been linked to monocytic differentiation and immunoregulatory states in AML. We investigated whether the MRC1 variants rs691005 and rs2253120 are associated with AML occurrence, development and prognosis....

Read the complete abstract on PubMed

Topics

Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Leukemia, Myeloid, Acute

Polymorphism, Single Nucleotide

Female

Receptors, Immunologic

Male

Prognosis

Middle Aged

Genetic Predisposition to Disease

Adult

Aged

Genotype

Membrane Glycoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42769364
DOI: 10.3389/fimmu.2026.1949691
PMCID: PMC13590749

Genes

MRC1
CD34

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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