Article
Identification of IKZF1 genetic mutations as new molecular subtypes in acute myeloid leukaemia.
Clinical and translational medicine - 1 Jun 2023
Wang Yang, Cheng Wenyan, Zhang Yvyin, Zhang Yuliang, Sun Tengfei, Zhu Yongmei, Yin Wei, Zhang Jianan, Li Jianfeng, Shen Yang
Abstract excerpt
BACKGROUND: Genetic mutations of IKZF1 have been frequently delineated in B-lineage acute leukaemia (B-ALL) but rarely elucidated in acute myeloid leukaemia (AML). IKZF1 mutations confer a poor prognosis in AML, and hotspot mutations of IKZF1, N159Y and N159S tend to occur in B-ALL and AML respectively. However, the pathogenesis of IKZF1 N159S in AML and IKZF1 lineage susceptibility are largely unknown. METHODS:...
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