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Article

Genomic and clinical determinants of outcome in Irish AML: a real-world analysis (2007-2025), single centre experience.

Annals of hematology - 30 May 2026

Elhassadi Ezzat, O'Rourke Ellen, Bannaga Ahmed, Kumar Senthil, Hennessy Brain

Abstract excerpt

Acute myeloid leukaemia (AML) is a genetically heterogeneous malignancy in which cytogenetic and molecular features critically inform diagnosis, prognosis, and therapeutic decision-making. While traditional karyotyping has long guided risk stratification, high-throughput sequencing has revealed extensive molecular diversity, particularly within cytogenetically normal AML, reshaping AML classification and...

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PMID: 42217025
DOI: 10.1007/s00277-026-07081-2
PMCID: PMC13433418

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TP53

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