Derivation of a novel multi-gene prognostic model based on regulated cell death pathways in acute myeloid leukemia: A comprehensive bioinformatic analysis integrating gene expression, mutation profiling, and immune infiltration.

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy with dismal survival outcomes, where dysregulation of regulated cell death (RCD) pathways plays a pivotal role in leukemogenesis and therapeutic resistance. METHODS: Differential expression analyses were performed comparing AML samples with healthy bone marrow. Diagnostic differentially expressed genes (DEGs) were then...

Topics

• Humans
• Leukemia, Myeloid, Acute
• Prognosis
• Computational Biology
• Mutation
• Gene Expression Profiling