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Dual biomarkers long non-coding RNA GAS5 and its target, NR3C1, contribute to acute myeloid leukemia.

Experimental and molecular pathology - 1 Jun 2020

Ketab Fereshteh Nasiri Ganjineh, Gharesouran Jalal, Ghafouri-Fard Soudeh, Dastar Saba, Mazraeh Shamsi Abdi, Hosseinzadeh Hassan, Moradi Mohsen, Javadlar Masoumeh, Hiradfar Amirataollah, Rezamand Azim, Taheri Mohammad, Rezazadeh Maryam

Abstract excerpt

Acute myeloid leukemia (AML) is a complex hematological neoplasm with poor prognosis. At present, overwhelming evidence indicates that different genetic abnormalities are relevant to the pathogenesis of AML. Nevertheless, its exact molecular mechanism is still unknown. Recently, it was reported that lncRNAs play crucial roles in tumorigenesis. But, their role in the molecular pathogenesis of AML has not been...

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PMID: 32032633
DOI: 10.1016/j.yexmp.2020.104399

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