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Article

What do ALS motor phenotypes measure? A population-based decomposition of their prognostic dimensions.

Journal of neurology - 18 Sept 2026

Calvo Andrea, Moglia Cristina, Callegaro Stefano, Canosa Antonio, Manera Umberto, Mora Gabriele, Cabras Sara, Palumbo Francesca, Matteoni Enrico, Maccabeo Alessandra, Pellegrino Giorgio, Minerva Emilio, Pascariu Daniela, D'Ovidio Fabrizio, Vasta Rosario, Mazzini Letizia, De Marchi Fabiola, Chiò Adriano

Abstract excerpt

BACKGROUND: The ALS-OPM 3.3 classification stratifies incident ALS through three axes: onset region (O), propagation time (P) and motor-neuron pattern (M). We assessed whether OPM 3.3 improves prognostic discrimination over established classifications and characterised how it decomposes their prognostic signal in a population-based cohort. METHODS: In the prospective Piedmont and Aosta Valley ALS Register...

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Topics

Humans
Amyotrophic Lateral Sclerosis
Female
Prognosis
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Middle Aged

Aged

Registries

Motor Neurons

Prospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 42758317
DOI: 10.1007/s00415-026-14134-z
PMCID: PMC13588936

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