Article
The Soifua Manuia reference panel with 2,570 Samoan haplotypes improves genotype imputation quality among Samoans.
Communications biology - 17 Sept 2026
Carlson Jenna C, Krishnan Mohanraj, Liu Shuwei, Anderson Kevin J, Zhang Jerry Z, Spor Lauren M, Yapp Toni-Ann J, Chiyka Elizabeth A, Dikec Devin A, Cheng Hong, Naseri Take, Reupena Muagututi'a Sefuiva, Viali Satupa'itea, Deka Ranjan, Hawley Nicola L, McGarvey Stephen T, Weeks Daniel E, Minster Ryan L
Abstract excerpt
Genotype imputation is fundamental to association studies, and yet even gold standard panels like TOPMed are limited in the populations for which they yield good imputation. Specifically, Pacific Islanders are poorly represented in extant panels. To address this, we used whole-genome sequencing from 1,285 Samoan individuals combined with 1000 Genomes Project (1KGP) individuals to construct an imputation reference...
Read the complete abstract on PubMedTopics
- Humans
- Gene Frequency
- Genetic Variation
- Genome-Wide Association Study