Article
A population-specific reference panel for improved genotype imputation in African Americans.
Communications biology - 5 Nov 2021
O'Connell Jared, Yun Taedong, Moreno Meghan, Li Helen, Litterman Nadia, Kolesnikov Alexey, Noblin Elizabeth, Chang Pi-Chuan, Shastri Anjali, Dorfman Elizabeth H, Shringarpure Suyash, Auton Adam, Carroll Andrew, McLean Cory Y
Abstract excerpt
There is currently a dearth of accessible whole genome sequencing (WGS) data for individuals residing in the Americas with Sub-Saharan African ancestry. We generated whole genome sequencing data at intermediate (15×) coverage for 2,294 individuals with large amounts of Sub-Saharan African ancestry, predominantly Atlantic African admixed with varying amounts of European and American ancestry. We performed...
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