Article
Assessment of genotype imputation performance using 1000 Genomes in African American studies.
PloS one - 1 Jan 2012
Hancock Dana B, Levy Joshua L, Gaddis Nathan C, Bierut Laura J, Saccone Nancy L, Page Grier P, Johnson Eric O
Abstract excerpt
Genotype imputation, used in genome-wide association studies to expand coverage of single nucleotide polymorphisms (SNPs), has performed poorly in African Americans compared to less admixed populations. Overall, imputation has typically relied on HapMap reference haplotype panels from Africans (YRI), European Americans (CEU), and Asians (CHB/JPT). The 1000 Genomes project offers a wider range of reference...
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