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Article

Imputation accuracy across global human populations.

American journal of human genetics - 2 May 2024

Cahoon Jordan L, Rui Xinyue, Tang Echo, Simons Christopher, Langie Jalen, Chen Minhui, Lo Ying-Chu, Chiang Charleston W K

Abstract excerpt

Genotype imputation is now fundamental for genome-wide association studies but lacks fairness due to the underrepresentation of references from non-European ancestries. The state-of-the-art imputation reference panel released by the Trans-Omics for Precision Medicine (TOPMed) initiative improved the imputation of admixed African-ancestry and Hispanic/Latino samples, but imputation for populations primarily...

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Identifiers

PMID: 38604166
DOI: 10.1016/j.ajhg.2024.03.011
PMCID: PMC11080279

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