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Article

Population-specific rare variants influence age at diagnosis in Korean inflammatory bowel disease.

The Korean journal of internal medicine - 1 Sept 2026

Cho Mina, Shin DongHwan, Yu Jongwook, Cheon Jae Hee, Kim Ju Han

Abstract excerpt

BACKGROUND/AIMS: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is increasing in East Asia. Most known susceptibility loci, identified primarily in Europeans, remain insufficient to explain clinical heterogeneity in Asians. We performed whole-exome sequencing in Korean IBD patients to identify population-specific variants influencing age at diagnosis. METHODS:...

Read the complete abstract on PubMed

Topics

Adolescent
Adult
Female
Humans
Male
Middle Aged
Young Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Age Factors

Age of Onset

Case-Control Studies

Colitis, Ulcerative

Crohn Disease

Disease Progression

Exome Sequencing

Genetic Predisposition to Disease

Genetic Variation

Phenotype

Republic of Korea

Source

Open in PubMed Open full text

Identifiers

PMID: 42754520
DOI: 10.3904/kjim.2026.055
PMCID: PMC13585687

Genes

GSG1
IGLL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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