Article
Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics.
Inflammatory bowel diseases - 12 Oct 2018
Li Dalin, Haritunians Talin, Landers Carol, Potdar Alka A, Yang Shaohong, Huang Hailiang, Schumm L Philip, Daly Mark, Targan Stephan R, McGovern Dermot P B
Abstract excerpt
Background: Age of onset is linked to variations in clinical phenotypes and natural history in Crohn's disease (CD). We aim to define etiologically more homogenous subgroups in CD based on ages of onset. Methods: We examined the distribution of CD polygenetic risk score (PRS) across ages of diagnosis in a Caucasian cohort of 2344 independent CD patients. We identified subgroups with a distinct distribution of PRS...
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